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At the same time, some non-pathogenic or opportunistic microorganisms begin to multiply intensively and can become a source of a new disease (superinfection).

Superinfections include candidiasis (diseases caused by yeast-like fungi of the genus Candida).

Candidiasis develops mainly during treatment with broad-spectrum antibacterial drugs (tetracyclines). 6 once in day per half an hour before food to kid 5 years.

Nikolaev wrote more than 140 valuable scientific papers on cardiovascular, endocrine pharmacology and pathological physiology. Department of Pharmacology, Faculty of Pharmacy, MMA named after THEM. Arivon retard, Indapen, Indapen SR, Indap, Indapamide SR, Indapamid-Astrapharm, Indapamid-Ratiopharm SR, Indopres, Ravel SR, Xipogamma, Arifon, Arifon retard, Indap, Vasopamid, Indapamide, Indapamid-Norton, Indapamid-Teva SR, Ipamid , Chemopamide retard. In case of overdose, predominantly symptomatic treatment is used: immediate gastric lavage; with severe life-threatening anticholinergic syndrome, Neostigmine (or Physostigmine) may be used; elimination of fever.

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Also to reduce the vegetative-vascular manifestations of menopausal syndrome in men. Overdose Release form: 0.1% solution in oil in vials of 20 ml. Applied as a means of adjuvant therapy for respiratory tract infections; for the prevention of recurrence of infections of the upper and lower respiratory tract.

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With prolonged use, an unpleasant sedative effect occurs, accompanied by lethargy, drowsiness, inability to concentrate and think clearly. Quite often there are dry mouth, atony of the gastrointestinal tract with the development of constipation and impotence.

With a sharp cessation of taking the drug, a pronounced withdrawal syndrome develops, manifested by a sharp increase in blood pressure, headache, tachycardia, sweating, and a hypertensive crisis is possible. Cancellation of the drug should be carried out gradually over 7-10 days, gradually reducing the dose and replacing it with other antihypertensive agents.

Clonidine potentiates the action of sedatives, alcohol (simultaneous use with alcoholic beverages is dangerous), and when used with digoxin, atrioventricular blockade may occur. The drug reduces the production of intraocular fluid, it is used to treat glaucoma.

A feature of anticancer drugs is the relatively low selectivity of action.

First of all, the activity of rapidly growing and multiplying cells, including malignant tumor cells, is suppressed.

At the same time, the vital activity of normal cells with rapid division (bone marrow cells, gastrointestinal mucosa, gonads) is disrupted, nephrotoxicity and hepatotoxicity are manifested, which indicates a high toxicity of anticancer drugs. In most cases, with the help of chemotherapy, it is possible to delay the development of a malignant tumor or malignant lesions of the hematopoietic tissues.

As a result, a satisfactory quality of life and the condition of an oncological patient temporarily improve, and in some cases life expectancy increases, and the survival rate of patients increases.

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