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Streptomycin has a wide spectrum of action, affecting not only gram-positive, but also gram-negative microorganisms. It suppresses the activity of Mycobacterium tuberculosis, pathogens of tularemia, brucellosis.

The mechanism of the antimicrobial action of streptomycin, like other aminoglycosides, is based on the inhibition of protein synthesis by ribosomes in a microbial cell. Streptomycin is poorly absorbed from the gastrointestinal tract and poorly penetrates through the mucous membranes, therefore, when administered in the form of an aerosol, it suppresses the infection only locally, in the lumen of the bronchi and alveoli. To obtain a resorptive effect, streptomycin is administered intramuscularly. In this case, it is well reabsorbed, active plasma concentrations last up to 24 hours, so the drug can be prescribed 1-2 times a day. In plasma, about 30% of streptomycin is protein bound.

The drug is evenly and quickly distributed in the body. With repeated injections, sufficiently high concentrations of the drug are created in the pleural fluid, but it penetrates poorly through the blood-brain barrier.

To Buy Retin-A Cream (Tretinoin) 0.05%, 0.025% online - Skin Care create an effective concentration in the cerebrospinal fluid, streptomycin should be administered endolumbally. Approximately 70-90% of the administered dose of streptomycin is excreted by the kidneys unchanged. In case of kidney disease, when the excretion function is impaired, the dose of streptomycin is recommended to be reduced by 3050%. Streptomycin and other aminoglycosides can cause severe complications: balance and hearing impairment (ototoxic effect), which in 8% of cases can lead to deafness.

The simultaneous appointment of streptomycin and other aminoglycosides is unacceptable due to a sharp increase in the toxic effect. Streptomycin crosses the placenta, so its introduction at the end of pregnancy can disrupt the development of the organ of hearing and lead to the birth of a deaf child.

Nephrotoxicity is manifested by a negative damaging effect on the renal tubules. The frequency of kidney damage in the treatment of aminoglycosides reaches 17%. The drugs are administered intramuscularly and into body cavities (pleural, abdominal, etc.).

Streptomycin-calcium chloride complex is used for injection under the membranes of the brain in meningitis , which has a less irritating effect. Streptomycin preparations are used mainly for the treatment of all forms of tuberculosis, as well as plague, tularemia, Buy Buy Brand Retino-A Cream (Tretinoin) 0.025%, 0.05%, 0,025%, 0,05% online - Skin Care Retin-A Cream (Tretinoin) brucellosis 0.05%, 0.025% online Buy Retin-A Cream (Tretinoin) - Skin 0.05%, 0.025% online - Skin Care Care, meningitis, intestinal and genitourinary infections.

Mycobacterium tuberculosis and other mycobacteria quickly develop resistance

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streptomycins, so they should be prescribed only after laboratory confirmation of the sensitivity of isolated microorganisms.

Streptomycin preparations are irritating and painful when injected. Often there are allergic reactions (rash, swelling of the mucous membranes, itching), anaphylactic shock is possible.

Zinc oxide causes protein denaturation and the formation of albuminates. Combining antibiotics with each other and with Buy Retin-A Cream (Tretinoin) other 0.05%, 0.025% online - Skin Care drugs in order to enhance the therapeutic effect and decrease side effects phenomena.

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