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For example, tetracyclines should not be prescribed for liver diseases, and sulfonamides - for oppression of hematopoiesis.

Penicillins often cause allergic complications, so they should not be used in patients with hypersensitivity to them.

Rp.: Dimedroli 0.03 (0.05) Gastritis chronic hyperacid Chronopharmacology establishes the principles and rules for the rational use of drugs, taking into account the biorhythms of individual body systems, time of day, seasons, other rhythms, and also seeks drugs and schemes for their prevention and treatment of

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biorhythms (desynchronosis).

Chronopharmacology is designed to assist doctors in improving the effectiveness of pharmacoprophylaxis and pharmacotherapy.

It is based on knowledge of the biological rhythms of daily (circadian), seasonal, as well as individual periods of development (intrauterine, childhood, youthful, mature, senile). An example of a rhythmic process that has existed over many years of evolution is the rhythm of body temperature.

A healthy person has Buy Microzide (Hydrochlorothiazide) 25mg the online - Blood Pressure lowest body temperature at night, by morning it gradually rises and reaches a maximum by 6 p.m. The rhythm of body temperature reflects the rhythmic activity of many body systems: the function of the Buy Microzide (Hydrochlorothiazide) 25mg online - central Blood Pressure nervous system, endocrine glands, and the cardiovascular system.

According to clinical data, most births begin from 23:00 to 3:00, the least - from 11:00 to 15:00. The timing of childbirth at night can be explained by the activation of the posterior pituitary gland during Buy Esidrix (Hydrochlorothiazide) 12,5mg, 25mg online - Blood Pressure this period and the release Buy Microzide (Hydrochlorothiazide) 25mg of online - Blood Pressure the hormone oxytocin, which stimulates the muscles of the uterus. Hormonal preparations of the adrenal cortex (glucocorticoids) and their synthetic substitutes, taking into account chronopharmacological principles, are rationally used in the morning hours (?8 hours), when the release of natural hormones is increased, which allows you to get the maximum pharmacological effect when

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using the smallest doses. Along with the fact that many diseases arise as a result of violations of biological rhythms, a certain rhythm was found in the appearance of symptoms of a number of diseases.

It is known that circadian rhythms of convulsive seizures are observed in patients with epilepsy: more often seizures occur at 6:00-7:00, at 11:00-12:00 and at 22:00-23:00. They also found seasonal rhythms of exacerbation of seizures.

Seasonal fluctuations in the pharmacokinetic processes of drugs are known. In the spring-summer period, the acetylation of sulfonamides in the human body more than doubles, which leads to their precipitation in the form of crystals in the kidneys and blockage of the urinary tract.

Accounting for chronopharmacological patterns is important for practical medicine, since the optimal time for taking drugs can, to a certain extent, increase the safety of pharmacotherapy.

Knowledge of daily, seasonal and other biorhythms in a particular patient makes it possible to treat a particular disease with smaller than usual doses, significantly increasing the clinical effect with minimal negative effects.

For example, it was found that a persistent hypotensive effect of the drug clonidine with traditional treatment occurs on the 10th day, and with chronotherapy - on the 4th day.

At the same time, single, daily and course doses were almost 2 times less than usual.

In addition, the frequency of complications in patients treated in accordance with the principles of chronopharmacology and chronotherapy was 5-6 times less.

Rp.: Dilminali D 2 ED Manifestations of overdose - nausea, vomiting, with significantly exceeded doses, death is possible as a result of collapse. The lethal dose of the drug is 180300 mg per kg of body weight.

In the process of digestion of food, the secrets of the glands of the stomach and pancreas play a major role.

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