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Children over 10 years old: 1 tablet 2 times a day. Elderly people do not need to adjust the dosing regimen.

sodium entering the cardiomyocyte in the depolarization phase, thus delaying the entry of potassium into the cell.

An increase in the concentration of sodium in the cell activates the sodium-calcium mechanism on the outer membrane (Na + -Ca 2+ -antiport), which enhances the entry of calcium into myocardiocytes and increases the release of calcium from the cisterns of the sarcoplasmic reticulum (in the depot, Ca 2+ is associated with the protein calsequestrin), as Buy Isoptin Sr (Verapamil) 120mg, 240mg online - Blood Pressure well as from mitochondria, where it accumulates during diastole. An increase in free calcium ions in the cytoplasm promotes their interaction with the ATP-tropomyosin complex. The inhibitory effect on the other two contractile proteins actin and myosin is eliminated; the rate of interaction of transverse myosin bridges with the actin filament increases, contributing to the formation of actomyosin.

The greater the number of calcium ions,

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greater the number of interacting bridges and the greater the force of contraction. That is why the cardiotonic action of cardiac glycosides is characterized by a rapid and strong contraction of the myocardium, increased systole (it becomes shorter) and an increase in cardiac output. By 48 drops in every nostril 23 times in day Apply 1 tablet 3 times a day with a sufficient amount of liquid.

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In this case, it is necessary to stop using the drug.

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