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Neurotropic drugs that affect the autonomic nervous system include drugs of the central mechanism of action that reduce the excitability of the vasomotor center and inhibit the conduction of vasoconstrictor impulses through the sympathetic nervous system: agonists of ? 2 -adrenergic receptors (clonidine, guanfacine); selective imidazoline (? Drugs that block peripheral sympathetic innervation: selective blockers of ?
1 -adrenergic receptors (prazosin, doxazosin); non-selective blockers of ?
2 -adrenergic receptors (propranolol, pindolol, nadolol, etc.); cardioselective blockers (? 1 ) of adrenergic receptors (atenolol, metoprolol, talinolol, bisoprolol, betaxolol, nebivolol); "hybrid" blockers ? 2 -adrenergic receptors (labetolol, carvedilol, proxodolol); sympatholytics (reserpine - rausedil ¤ ) and its combined preparations and ganglioblockers (azamethonium bromide). Sulfanilamide preparations are considered low- toxic compounds, but can cause allergic hygienic reactions, dyspeptic disorders, dysfunction of the CNS.
Due to the chemical structure sulfonamides and especially their products of acetylated vaniya may fall out in kidneys in crystalline form (causing crystalluria With proteinuria and hematuria) and block the urinary tract. For a warning similar complications sick at admission sulfanyl- S. With moderately rapid digitalization, the drug is prescribed on the 1st day at a dose of 1.25 mg, on the 2nd day - 1.25 mg, on the 3rd day - 1 mg.
With slow digitalization in the first 5 days, 750 mcg per day is prescribed, from the 6th to the 7th day - 500 mcg per day.
Then they switch to a maintenance dose, which is 250–500 mcg per day.
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