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The introduction of drugs for anesthesia through the respiratory tract along with oxygen has a number of advantages over non-inhalation anesthesia, the main of which is good anesthesia management (maintaining the desired concentration of the drug in the blood). Means for inhalation anesthesia include volatile liquids and gaseous substances.
Optional : Antihormonal drugs are drugs that reduce or stop the synthesis or specific action of hormones. inhibits the synthesis of hormones in the thyroid gland. (1 hour before meals, or 1 / 2-1 hour after eating) 2 times a day ; when ask- ridose - 2 days; at enterobidosis — 5 days.
Hypersensitivity to the components of the drug, acute and chronic glomerulonephritis, age up to 12 years, pregnancy and lactation.
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When using chromatographically purified (mono-peak) insulin preparations, the risk of developing allergic reactions is very low.
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excretum - excretion) is understood as various ways of excretion of drugs and their metabolites from the body (with feces, urine, exhaled air, sweat, saliva, lacrimal fluid). The main route of excretion of drugs and metabolites is the kidneys.
To assess the rate of excretion of drugs in the urine, the renal clearance index is used, which reflects the rate of purification of blood plasma from drugs per unit time (ml / min). The blood entering the kidneys is filtered in the glomeruli from the free drug in it.
In the process of passing through the tubules, lipophilic drugs are reabsorbed (reabsorbed), and polar, hydrophilic metabolites are excreted in the urine. In clinical practice, to determine the dosing regimen, the half-life indicator (T 1/2 ) is used, which shows the time (hours or minutes) for a 2-fold decrease in the concentration of drugs in the blood (50%).
For example: T 1/2 digoxin 165 hours, sulfalene 65 hours, ampicillin 1 hour, acetylcholine, epinephrine 2-3 minutes.
Many factors influence the release of drugs, including molecular weight, concentration of a substance in blood and urine, pKa, solubility in water and lipids, pH of urine, renal and hepatic blood flow, etc.
In cases where a drug is bound to a protein, it cannot be filtered in the renal glomeruli, since their integral molecular weight (m.m.) is more than 70,000. Only those substances are filtered in the renal glomeruli, m.m.
With an increase in the pH of urine (urine becomes more alkaline), acidic substances are ionized and are better excreted from the body, and preparations with the properties of bases undergo less ionization, become lipophilic more easily and their reabsorption increases.