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The main pharmacological properties of corticotropin are a decrease in the permeability of the vascular wall, an anti-inflammatory and desensitizing effect (decrease in the sensitivity of the body during allergic reactions).

Corticotropin is prescribed for adrenal insufficiency resulting from prolonged use of glucocorticoid drugs for the treatment of inflammatory and allergic diseases (rheumatism, bronchial asthma, eczema, neurodermatitis, polyarthritis). The introduction of 10-20 IU of corticotropin usually causes the maximum release of glucocorticoids.

Corticotropin, when taken orally, is destroyed in the stomach and intestines, so it is injected into the muscles, less often into Buy Detrol (Tolterodine) 2mg, 1mg online - General health a vein. The action of a single dose of the drug lasts 6-8 hours; the drug should be administered 3-4 times a day.

Doses of the drug depend on the nature and severity of the disease. Long-term continuous administration of corticotropin is not recommended, since depletion of the adrenal cortex is possible. During treatment with the drug, edema, increased blood pressure, agitation, insomnia and allergic reactions can be observed.

A synthetic analog of ACTH is a long-acting drug tetracosactide (synacten depot ? It has all the pharmacological properties of a natural hormone. Due to the absence of foreign proteins, it can be prescribed to patients with hypersensitivity to ACTH and with multiple sclerosis. Excessive sweating, tachycardia, urticaria, rash, dyspnea and anaphylactic shock.

Internal rivenno 2 ml (With 250 ml 0.9% solution sodium chlo- read) drip. Induction of vomiting, gastric lavage, administration of activated charcoal; symptomatic and supportive therapy against the background of careful monitoring of breathing and blood pressure levels.

For diseases of nails, hair, skin, the recommended dose is 5 mg (1 tablet) per day.

With genetically determined enzymopathies associated with biotin (multiple carboxylase deficiency), 2-4 tablets are prescribed (daily dose - up to 20 mg of biotin) in 1-2 doses per day. The duration of the course of treatment depends on the nature and course of the disease and is usually 1 month.

Butyrum Hydrocortisone preparations, as well as many synthetic analogues of glucocorticoids, are widely used in medicine. According to the duration of action, they are classified into short-acting drugs (6-8 hours) - hydrocortisone; having an average duration of action (12-36 hours) - methylprednisolone, prednisone, triamcinolone, fludrocortisone; long-acting (36-72 hours) - dexamethasone, betamethasone. There are preparations of glucocorticoids of resorptive and local action (systemic and external use), non-fluorinated: hydrocortisone, prednisolone, Buy Artane General its online health 2mg - (Trihexyphenidyl) derivatives: mometasone, mazipredone, methylprednisolone; and fluorinated: dexamethasone, triamcinolone, betamethasone, fluocinolone acetonide, flumethasone , fluticasone, clobetasol.

According to pharmacological efficacy, drugs are divided into four groups (Table 23.2). It is administered intravenously, intramuscularly and orally.

Into a vein introduced jet (slowly) or drip in isotonic solution re sodium chloride.

It is forbidden dissolve in glucose soda, ascorbino- howl acid due to his inactivation.

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